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3CPM Electrogastrography and Electroviscerography systems are based on over 150 year’s worth of critical and ground breaking science from some of the world’s most brilliant and leading medical and scientific experts. Every year, more and more research is performed and emerges, further establishing the vital nature of this technology. This literature library contains articles of much of the foundational material up through recent clinical publications of peer reviewed articles and book chapters. We include all the literature here, including from complementary similarly minded technologies. We believe that all knowledge must be shared broadly and indiscriminately to foster the next generation of critical thinkers, developers and inventors. By working together, we will be able to understand and even cure many ailments that remain enigmatic even today. Please check back regularly for updates on the latest science of Electrogastrography and Electroviscerography.
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24-Hour Ambulatory Electrogastrography in Healthy Volunteers
G. LINDBERG, M. IWARZON & B. HAMMARLLJND
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A Disturbance of The gastric myoelectric activity In Post-Operative Patients With Biliary Astresia
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A Model of Gastric Electrical Activity In Health and Disease
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A multiscale model of the electrophysiological basis of the human electrogastrogram
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Abnormal Gastrointestinal Endocrine Cells in Patients with Diabetes Type1 Relationship to Gastric Emptying and Myoelctrical Activity
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Abnormalities of the electrogastrogram in functional gastrointestinal disorders
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Abnormalities of the electrogastrogram in globus pharyngeus
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Absence of the interstitial cells of Cajal in patients with gastroparesis and correlation with clinical findings
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Acquired myopathic intestinal pseudo-obstruction may be due to autoimmune enteric leiomyositis
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Adaptive Independent Component Analysis of Multichannel Electrogastrograms
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Alteration of gastric myoelectrical and autonomic activities with audio stimulation in healthy humans
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Alvarez WC. New methods of studying gastric peristalsis. J Am Med Assoc
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An evaluation of adult electrogastrography criteria in healthy children
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An Explanation of Hunger
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Analysis of Gastric Electrical Signals from Surface Electrodes Using Phase Lock Techniques
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Analysis of the electrogastrogram using discrete wavelet transform and statistical methods to detect gastric dysrhythmia
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Antral myoelectric activity, gastric emptying, and dyspeptic symptoms in diabetics
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Artifact reduction in electrogastrogram based on empirical mode decomposition method
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Assessment of gastric electrical activity and autonomic function among diabetic and nondiabetic patients with symptoms of gastroesophageal reflux
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Association between gastric myoelectrical activity and intraluminal nitric oxide
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Biomagnetic 3-dimensional spatial and temporal characterization of electrical activity of human stomach
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Blind separation of multichannel electrogastrograms using independent component analysis based on a neural network
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Can Transcutaneous Recordings Detect Gastric Electrical Abnormalities
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Changes in Gastric Myoelectric Activity During Space Flight
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Changes in gastric myoelectrical activity in hypertrophic pyloric stenosis and after surgical correction
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Characterization of Gastric Myoelectrical Rhythms in Patients with Systemic Sclerosis Using Multichannel Surface Electrogastrography
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Characterization of Gastric Myoelectrical Rhythms in Patients With Systemic Sclerosis Using Multichannel Surface Electrogastrophy
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Chronic gastritis is not associated with gastric dysrhythmia or delayed solid emptying in children with dyspepsia
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Cisapride provides symptomatic relief in functional dyspepsia associated with gastric myoelectrical abnormality
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Comparison of adaptive filtering in time, transform, and frequency-domain An electrogastrographic study
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Computer simulation of the effect of changing abdominal thickness on the electrogastrogram
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Conditions Associated With Gastrointestinal Activity
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Correlations among electrogastrogram, gastric dysmotility, and duodenal dysmotility in patients with functional dyspepsia
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Detection of gastric slow wave propagation from the cutaneous electrogastrogram
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Development of gastric slow waves in preterm infants measured by electrogastrography
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Diabetic gastropathy gastric neuromuscular dysfunction in diabetes mellitus a review of symptoms pathophysiology and treatment
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Differential symptomatic and electrogastrographic effects of distal and proximal human gastric distension
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Does vivid emotional imagery depend on body signals
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Domperidone and Diabetic Gastroparesis 201989
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Domperidone is more effective than cisapride in children with diabetic gastroparesis
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Dose Response Effects of Indomethacin and PGE on Electromechanical Activity of In Vivo Rabbit Ileum
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Dynamics of Level of Randomness of Electrogastrograms Can Be Indicative of Gastric Electrical Uncoupling in Dogs
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Dynamics of Level of Randomness of Electrograstrograms Can Be Indicative of
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Effect of capsaicin containing red pepper sauce suspension on upper gastrointestinal motility in healthy volunteers
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Effect of cisapride on gastric dysrhythmia and emptying of indigestible solids in type-II diabetic patients
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Effect of drink temperature on antropyloroduodenal motility and gastric electrical activity in humans
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Effect of Electrical Stimulation on Acupuncture Points in Diabetic Patients With Gastric Dysrhythmia
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Effect of erythromycin on gastric myoelectrical activity in normal human subjects
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Effect of gastric myoelectric activity on carbohydrate absorption of fruit juice in children
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Effects of acupressure on gastric myoelectrical activity in healthy humans
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Effects of audio stimulation on gastric myoelectrical activity and sympathovagal balance in healthy adolescents and adults
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Effects of cholecystectomy on gastric emptying and myoelectrical activity in man
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Effects of different psychophysiological stressors on the cutaneous electrogastrogram in healthy subjects
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Effects of electroacupuncture on cardiac and gastric activities in acute myocardial ischemia
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Effects of intraduodenal glucose infusion on gastric myoelectrical activity and antropyloroduodenal motility
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Effects of meal volume and composition on gastric myoelectrical activity
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Effects of Nutrients and Serotonin 5 HT3 Antagonism on Symptoms Evoked by Distal Gastric Distension in Humans
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Efficiency and efficacy of the electrogastrogram
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EGG AGA Position Paper
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EGG bibliography
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EGG Obstruction
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Electrical Activity From Colon Overlaps With Normal Gastric Electrical Activity in Cutaneous Recordings
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Electrical Arrhythmias in the Human Stomach
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Electrogastrographic changes in children who undergo day-surgery anesthesia
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Electrogastrographic characteristics of interdigestive migrating complex in humans
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Electrogastrographic Study of Gastric Myoelectrical Activity in Patients with Unexplained Nausea and Vomiting
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Electrogastrography a seductive promise, only partially kept
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Electrogastrography after operative repair of esophageal atresia
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Electrogastrography can recognize gastric electrical uncoupling in dogs
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Electrogastrography For Evaluating Neurologically Impaired Children With Recurrent Vomiting
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Electrogastrography in Gastric Emptying Scintigraphy are Complimentary For Assessment of Dyspepsia
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Electrogastrography in gastrostomy-tube-fed children
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Electrogastrography in Patients With Gastropareis and Effect of Long Term Cisapride
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Electrogastrography in Patients With Gastroparesis and Effect of Long Term Cisapride
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Electrogastrography in patients with gastroparesis and effect of long-term cisapride
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Electrogastrography versus gastric emptying scintigraphy in children with symptoms suggestive of gastric motility disorders
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Electrogastrophic Study of Gastric Myoelectrical Activity in Patients With Unexplained Nausea and Vomiting
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Evaluation of gastric motor activity in the elderly by electrogastrography and the 13C acetate breath test
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Evolution of acute cytomegalovirus gastritis to chronic gastrointestinal dysmotility in a nonimmunocompromised adult
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Extracting Quantitative Information From Digital Electrogastrograms
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Fasting and postprandial small intestinal slow waves non-invasively measured in subjects with total gastrectomy
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Frequency of gastric pacesetter potential depends on volume and site of distension
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Functional Gastroduodenal Disorders
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Gastric and small intestinal myoelectric dysrhythmia associated with chronic intractable nausea and vomiting
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Gastric Antral Dysrhythmias in Children With Chronic Idiopathic Intestinal Pseudoobstruction
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Gastric dysmotility in healthy first-degree relatives of patients with schizophrenia
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Gastric dysmotility in major depression
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Gastric Dysrhythmias and Nausea of Pregnancy
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Gastric Dysrhythmias Nausea Pregnancy
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Gastric dysrhythmias occur in gastro-oesophageal reflux disease complicated by food regurgitation but not in uncomplicated reflux
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Gastric electrical activity and gastrointestinal hormones in dyspeptic patients
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Gastric electrical activity becomes abnormal in the upright position in patients with postural tachycardia syndrome
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Gastric electrical stimulation for children with intractable nausea and gastroparesis
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gastric electromechanical function and gastric emptying in diabetic gastroparesis
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Gastric involvement in systemic sclerosis a prospective study
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Gastric Motility Measurement and Evaluation of Functional Dyspepsia By a Bio-Impedance
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Gastric myoelectric activity in patients with end-stage liver disease
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Gastric myoelectrical activity as an index of emotional arousal
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Gastric myoelectrical activity in patients with cervical spinal cord injury
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Gastric Myoelectrical Activity in Patients With Gastric Outlet Obstruction
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Gastric Myoelectrical Activity In Patients With Gastric Outlet Obstruction and Idiopathic Gastroparesis
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Gastric myoelectrical activity in patients with type I diabetes mellitus and autonomic neuropathy
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Gastric Myoelectrical Activity in Patients With Type I Diabetes Mellitus and Autonomic Neuropatyh
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Gastric Myoelectrical Activity in Premature and Term Infants
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Gastric Myoelectrical and Empyting Activity In Patients With Gastroesophageal Reflux Disease and Dysmoitlity Like Functional Dyspepsia
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Gastric myoelectrical differences between Parkinson's disease and multiple system atrophy
ParkinsonClick below to download PDF of this article.
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Gastric Pacing Improves Emptying in Symptoms in Patients With Gastroparesis
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Gastroesophageal reflux disease presenting with intractable nausea
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Gestational Maturation of Electrical Activity of the Stomach
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Gut feelings, intuition, and emotionsan exploratory study
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High dose ondansetron for reducing motion sickness in highly susceptible subjects
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High-pass filtering of the electrogastrogram
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Human Gastric Pacesetter Potential Site of Origin Spread and Response To Gastric Transection And Proximal Vagotomy
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Hyperglycemia affects gastric electrical rhythm and nausea during intraduodenal triglyceride infusion
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Impaired Drinking Capacity in Patients With Functional Dyspepsia
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Impaired gastric myoelectrical activity in patients with chronic renal failure
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Impaired gastric myolectrical activity in patients with cystic fibrosis
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Impaired Gastric Slow Wave Rhythmicity in Patients After Bone Marrow or Stem Cell Transplant
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Impaired postprandial gastric myoelectrical activity in Chinese patients with nonulcer dyspepsia
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Impaired postprandial gastric slow waves in patients with functional dyspepsia
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Impairment of gastrointestinal motility by nitrate administration evaluation based on electrogastrographic changes and autonomic nerve activity
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Increased feelings with increased body signals
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Inhibitory effect of white wine on gastric myoelectrical activity and the role of vagal tone
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Inhibitory effects of cholecystokinin on postprandial gastric myoelectrical activity
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Intestinal Smooth Muscle Electrical Potentials Recorded from Surface Electrodes
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Intractable Nausea Presenting As Gastroesophageal Reflux Disease
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Intragastric Distribution and Gastric Emptying Assessed by Three Dimensional Ultrasonography
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Intragastric Distribution and Gastric Empyting Assessed by Three Dimensional Ultrasonagraphy
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Ischemic Gastroparesis 1990
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Ischemic Gastroparesis 201990
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Linear and non-linear measures indicate gastric dysmotility in patients suffering from acute schizophrenia
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Mast cell-nerve interactions in children with functional dyspepsia
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Measurement Of Gastric Emptying By Realtime Ultrasonography
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Mediation of Hyperglycemia Evoked Gastric Slow Wave Dysrhythmias by Endogenous Prostaglandins
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Misinterpretation of human electrogastrograms related to inappropriate data conditioning and acquisition using digital computers
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Multichannel adaptive enhancement of the electrogastrogram
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Multiscale modeling of human gastric electric activity can the electrogastrogram detect functional electrical uncoupling
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Myoelectric Activity of the Bilroth II Gastric Remnant
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Nicotine effects on prostaglandin-dependent gastric slow wave rhythmicity and antral motility in nonsmokers and smokers
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Noar DDW 2005 High 3cpm pyloric dilation
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Non-invasive electrogastrography Part 1 Correlation between the gastric electrical activity in dogs with implanted and cutaneous electrodes
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Non-invasive electrogastrography Part 2 Human electrogastrogram
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Non-invasive identification of gastric contractions from surface electrogastrogram using back-propagation neural networks
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Noninvasive feature-based detection of delayed gastric emptying in humans using neural networks
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On non-invasive measurement of gastric motility from finger photoplethysmographic signal
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Optimal Directions of the Electrogastrographic Signal in Man
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Organ-specificity of placebo effects on blood pressure
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Pain the overlooked symptom in gastroparesis
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Patterns of gastric myoelectrical activity in human subjects of different ages
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Pitfalls of the Analysis of Electrogastrographic Recordings
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Plasticity of Electrical Pacemaking by Interstitial Cells of Cajal and Gastric Dysrhythmias in Mutant Mice
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Portable EGG recording system based on a digital voice recorder
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Post-infectious gastroparesis clinical and electerogastrographic aspects
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Postprandial Response of Gastric Slow Waves
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Postprandial response of gastric slow waves correlation of serosal recordings with the electrogastrogram
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Predictors of gastric myoelectrical activity in type 2 diabetes mellitus
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Prevalence of gastric myoelectrical abnormalities in patients with nonulcer dyspepsia and H pylori infection resolution after H pylori eradication
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Progesterone and estrogen are potential mediators of gastric slow-wave dysrhythmias in nausea of pregnancy
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Protein meals reduce nausea and gastric slow wave dysrhythmic activity in first trimester pregnancy
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Regulation of Pacemaker Frequency In the Murine Gastric Antrum
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Relation between postprandial gastric emptying and cutaneous electrogastrogram in primates
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Relationship among gastric motility, autonomic activity, and portal hemodynamics in patients with liver cirrhosis
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Relationship between surface electrogastrography and antropyloric pressures
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Relationships Between Pressure and Flow Across the Gastroduodenal Junction In Dogs
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Reliability of percent distribution of power of the electrogastrogram in recognizing gastric electrical uncoupling
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Reversal of Gastric Electrical Dysrhythmias by Cisapride in Children with Functional Dyspepsia
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Reversible autonomic dysfunction in hyperthyroid patients affects gastric myoelectrical activity and emptying
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Rhythmic and spatial abnormalities of gastric slow waves in patients with functional dyspepsia
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Risk Indicators of Delayed Gastric Emptying of Solids in Patients With Functional Dyspepsia
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Role of plasma vasopressin as a mediator of nausea and gastric slow wave dysrhythmias in motion sickness
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Role of sham feeding in postprandial changes of gastric myoelectrical activity
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Serosal and cutaneous recordings of gastric myoelectrical activity in patients with gastroparesis
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Sleep and Gastric Function in Irritable Bowel Syndrome Derailing the Brain Gut Axis
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Spectral analysis of episodic rhythmic variations in the cutaneous electrogastrogram
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Spectrum of gastric dysrhythmias and gastric emptying in 54 patients with chronic unexplained nausea and vomiting
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Suppression of Pregnancy Induced Nausea and Vomiting With Sensory Afferent Stimulation
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Surface electrogastrography in children with esophageal atresia
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The contribution of expectations to motion sickness symptoms and gastric activity
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The Effect of Intravenous Vasopressin on Gastric Myoelectrical Activity in Human Subjects
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The electrogastrogram and what it shows
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The Immediate and Delayed Effects of Different Types of Vagotomy on Human Gastric Myoelectrical Activity
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The Regulatory Process in Canada
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Time-frequency methods for detecting spike activity of stomach
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Topographical electrogastrograms after radical esophagectomy with colonic replacement
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Treatment of Idiopathic Gastroparesis With Injection of Botulinum Toxin Into the Pyloric Sphincter Muscle
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Utility of electrogastrography in differentiating Parkinson's disease with or without gastrointestinal symptoms a prospective controlled study
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Validation of electrode placement in neonatal electrogastrography
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Visualization and Characterization Of Gastric Contractions Using A Radionuclide Technique
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Vomiting and gastric motility in infants with cow's milk allergy
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Vomiting and Gastroesophageal Motor Activity in Children with Disorders of the Central Nervous System
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What is Measured in Electrogastrography
What is EGG
The 3CPM® Company’s Electrogastrography/Electroviscerography (EGG/EVG ) Systems is a class II medical device that records, stores, analyzes, displays and prints the myoelectric signals from the stomach and gastrointestinal system as an aid to diagnosis of various gastric and gastrointestinal motility disorders.
The EGG/EVG is a non-invasive test of gastric myoelectrical activity of the digestive system. The EGG/EVG reflects the stomach’s pacesetter potential activities, much like the electrocardiogram (ECG) reflects electrical events occurring in the heart. It does this by looking at the activity of pacemaker cells of the gastrointestinal system known as ICCs. The performance of an EGG does not require pre-medication and has no significant side effects.
In particular, it allows the doctor to divide disorders of stomach motility into different subtypes based upon the energy detected during peristalsis or contraction of the smooth muscle of the gastrointestinal tract. Known as the EGG/EVG signal, it is an energy recording of what is called myoelectrical activity or GMA.. Once the subtypes of GMA are known, it is then possible to diagnosis your illness more specific to your body’s physiology. Once compared to the information from healthy normal people, your physician is able to select treatments that are designed specifically for you. This may allow for your illness to be better controlled or in some cases even cured. This is known as personalized medicine.
Hear Real Stories from our Patients
An Electrogastrogram/Electroviscerogram is Indicated for Patients Who Have:
- Gastroparesis
- Unexplained nausea, vomiting, bloating, early satiety
- Unexplained or functional dyspepsia
- Chronic GERD
In its position paper on nausea and vomiting, the American Gastroenterological Association included Electrogastrogram in its algorithm for the evaluation and management of nausea. Optimum use of this device requires a basic familiarity with the published literature which describes typical EGG patterns commonly encountered in clinical practice with specific patient groups and related interpretative techniques.
The secret of the technology is the Human Interface Module or HID. Inside of the device are special filters that have characteristic amplifiers to allow detection of biological signals with approximate frequency ranges from 1 to 200 cycles per minute (cpm) to pass through for recording and digitization.
To see how the EGG/EVG is performed please click here.
The Electrogastrogram Data Is Presented In Four Major Frequency Ranges
- Normal (2.5 to 3.75 cpm)
- Bradygastria (1.0-2.5 cpm)
- Tachygastria (3.75-10.0 cpm)
- Duodenal-Respiratory (10.0-15 cpm)
How it Helps Disease: You May Have a Curable Form Of Gastroparesis
Of the estimated 40 million Americans that suffer from this disease, 25-28% have a subtype that may be cured with simple endoscopic balloon dilation.
Gastroparesis
Gastroparesis may be divided into subtypes that include obstructive, reflux related, and poor conduction types. Only the EGG can properly identify the type of dysmotility and lead to either correction or proper treatment and control. In obstructive subtypes, 3CPM® Company EGG GMAT® software successfully predicts a 93% response to endoscopic pyloric balloon dilation.
Read Case Study 1: Use Of Electrogastrography In The Detection Of Functional Pyloric Outlet Obstruction
Read Case Study 2: Gastric Outlet Obstruction In A Physically Active, Young Woman
GERD- Reflux Disease
Up to 40-45% of people who suffer from GERD have gastroparesis and symptoms of bloating and satiety. Associated EGG definable subtypes include functional obstruction and reflux related or GERD+. Reflux related subtypes are cured with correction of the GERD, while obstructive subtypes require pyloric therapy. Obstructive subtypes require resolution prior to correction of reflux to avoid potential complications.
Read Case Study: Reflux-Related Dyspepsia or Gerd+ In Middle-Aged Man
Nausea, Vomiting and Dyspepsia
These symptoms are often due to poor conduction associated to low numbers of ICCs. The quality of the 3CPM signal correlates directly with quality and numbers of the ICC’s. Normal ICC quality correlates directly with the success of therapy like medication or the Enterra stimulator for gastroparesis. If poor ICC’s are noted, then therapy is directed towards restoration of the ICC’s.
Read Case Study: Chronic Dyspepsia In a Middle-Aged Woman With Normal Gastric Emptying
Patients with Gastroparesis, Dyspepsia, chronic undefined nausea and vomiting, post prandial distress syndrome, or GERD respond to treatment with variable and often poor results.
- EGG detects, analyzes and subtypes gastrointestinal myoelectrical activity (GMA) of motility.
- EGG gives clinicians a window onto the cellular and physiological homeostatic controls
- Etiology driven diagnostics are key to successful therapy
- Allows recognition when homeostasis is uncoupled and restored
- Better understanding of disease mechanisms helps to guide corrective therapy
- Published evidence supports predictable therapeutic success and outcomes with GMA Subtyping
- GMA subtyping may prevent post-operative complications or primary procedure failure
- Allows recognition and pretreatment of subtle complicating gastric motility disorders
3CPM Electrogastrogram Billing & Administrator Information
In the current challenging environment of endoscopic utilization and reimbursements, one of the best investments in new technology is in that which represents science based on sound scientific foundations and clinical research with an eye not only to the future but to the past.
The 3CPM Company® Electrogastrogragraphy and Electroviscerography systems and software packages represent tested, true state-of-the-art devices, with a proven track record in producing significant clinical and treatment outcomes.
Equally important is the ease of use, cost-saving design and documented favorable impact on ROI and the bottom line.
ASC, Clinic, Office and Hospital Logistics
The 3CPM EGG/EVG systems can be readily performed in and inpatient or outpatient office or clinic. Setup and testing is performed by medical staff, such as a technician. Following placement of 3 small electrode pads on the abdomen, the initial patient baseline and demographics entry takes 10-15 minutes. Patients sit calmly in a reclining chair, freeing up busy procedure rooms and staff. After a 5-minute water load, during which the patient drinks water, the patient rests comfortably for the remainder of the 30-minute test.
Training
Medical staff, such as a technician, can safely perform the test once trained. A set of highly regarded, detailed, easy to understand educational videos are available on the 3CPM website. For institutions that require certification for personnel, 3CPM will provide onsite training for a nominal fee + travel expenses. Training at the 3CPM home facility is another option and provided at no cost to the institution. Following successful completion of the didactic and hands-on training, staff is asked to perform and submit the results of 2 independent studies. Once completed training certificates are issued.
Reports
3CPM EGG/EVG systems provide accurate reproducible data on gastric function, compared to healthy normals. This is unique to our systems only. Reports may be customized to each insitutions’ needs and include:
- Analysis, % distribution and stability of gastrointestinal electrical rhythms
- Gastric accommodation profile
- GMA subtyping of gastrointestinal myoelectrical activity
- GMAT Threshold Measurement
- Running spectral analysis over time
- Artifact detection and automated minute selection
- Standardized interpretation based upon published parameters
- Healthy population based summary interpretive graphs
- Suggested diagnoses
Reports can be custom configures to meet institutional needs.
The EGG/EVG allows deeper understanding of the mechanisms driving patient disease and the GMA subtypes, which then permit greater understanding of viable treatment options and predicted outcomes.
REIMBURSEMENT INFORMATION
Level I CPT code since 2000
CPT Coding per procedure
- 91133 EGG w/stimulation
- 99214 E&M code
- Most quality insurance offers reimbursement
- REQUEST MORE INFORMATION ON INSURANCE
ICD10 CODES
- Gastro-esophageal reflux disease: K21.9
- Heartburn: R12
- Achlorhydria: K31.83
- Gastroparesis: K31.84
- Nausea: R11.0
- Nausea and Vomiting: R11.2
- Dyspepsia: K30
REGULATORY APPROVALS
- FDA clearance
- UL certification
- KFDA clearance
- MDSAP (regulatory clearance in US, Australia, Brasil, Canada and Japan
- CE MDD* (*recertification to MDR in Q2 2022)